There are some minor cli changes with VNXe MCX which I will document as part of this series, for VNXe GEN1 please refer to these earlier posts:
EMC VNXe Gen1 Configuration Using Unisphere CLI

The initial configuration steps outlined in Part1 :

Accept End User License Agreement
Change the Admin Password
Apply License File
Commit the IO Modules
Perform a Health Check
Code Upgrade
Create A New User
Change the Service Password
Enable SSH

Accept End User License Agreement
uemcli -d 192.168.1.50 -u Local/admin -p Password123# /sys/eula set -agree yes

Change the Admin Password
uemcli -d 192.168.1.50 -u Local/admin -p Password123# /user/account show
uemcli -d 192.168.1.50 -u Local/admin -p Password123# /user/account -id user_admin set -passwd NewPassword -oldpasswd Password123#
uemcli -d 192.168.1.50 -u Local/admin -p NewPassword /user/account show

Reference ‘Help’ for any assistance:
uemcli -d 192.168.1.50 -u Local/admin -p NewPassword / -help

Apply License File
Firstly gather the Serial Number of the VNXe:
uemcli -d 192.168.1.50 -u Local/admin -p Password123# /sys/general show -detail
Then browse to the EMC registration site, entering the VNXe S/N to retrieve the associated lic file:
https://support.emc.com/servicecenter/registerProduct/

Upload the acquired license file:
uemcli -d 192.168.1.50 -u Local/admin -p NewPassword -upload -f C:\Users\david\Downloads\FL100xxx00005_29-July-2015_exp.lic license
uemcli -d 192.168.1.50 -u Local/admin -p NewPassword /sys/lic show

Commit the IO Modules
The following commits all uncommitted IO modules:
uemcli -d 192.168.1.50 -u Local/admin -p NewPassword /env/iomodule commit

Display a list of system IO modules:
uemcli -d 192.168.1.50 -u Local/admin -p NewPassword /env/iomodule show

Perform a Health Check
It is good practice to perform a Health Check in advance of a code upgrade:
uemcli -d 192.168.1.50 -u Local/admin -p NewPassword /sys/general healthcheck

Code Upgrade
uemcli -d 192.168.1.50 -u Local/admin -p NewPassword /sys/soft/ver show
uemcli -d 192.168.1.50 -u Local/admin -p NewPassword -upload -f “C:\Users\david\Downloads\VNXe 2.4.3.21980\VNXe-MR4SP3.1-upgrade-2.4.3.21980-RETAIL.tgz.bin.gpg” upgrade
uemcli -d 192.168.1.50 -u Local/admin -p NewPassword /sys/soft/ver show
uemcli -d 192.168.1.50 -u Local/admin -p NewPassword /sys/soft/upgrade create -candId CAND_1
uemcli -d 192.168.1.50 -u Local/admin -p NewPassword /sys/soft/upgrade show
uemcli -d 192.168.1.50 -u Local/admin -p NewPassword /sys/general healthcheck

Note: Please see a more detailed overview of the upgrade process in a previous post:
https://davidring.ie/2015/03/02/emc-vnxe-code-upgrade/

Create A New User
uemcli -d 192.168.1.50 -u Local/admin -p NewPassword /user/account create -name david -type local -passwd DavidPassword -role administrator
uemcli -d 192.168.1.50 -u Local/admin -p NewPassword /user/account show

The role for the new account can be:
• administrator — Administrator
• storageadmin — Storage Administrator
• operator — Operator (view only)

Change the Service Password
The Service password is used for performing service actions on the VNXe.
uemcli -d 10.0.0.1 -u Local/admin -p Password123# /service/user set -passwd newPassword -oldpasswd Password123#

Enable SSH
uemcli -d 192.168.1.50 -u service -p NewPassword /service/ssh set -enabled yes